Results  |  Discussion  |  Adhesion  |  Motility  |  Overview

Adhesion Formation

New adhesions are formed at the edge of the membrane. Paxillin was the first fusion protein seen to organize itself in the cell near the edge. The proteins a5 integrin and a-actinin were present at the edge, but were not detectable in the regions where paxillin was prominent.

Therefore, either the a5 integrin may not be involved with the formation of new adhesions, or the concentration present may be too low to detect. However, it is known that the presence of this protein is necessary in order for the cells to adhere and migrate; therefore, it must be present. This protein is also found to be required for the organization of paxillin, and therefore it must initiate newly forming adhesions. Paxillin helps recruit signaling components to the membrane, which suggest that the new adhesions will also serve as signaling roles.