Cell Morphology and Motility
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This website was made by students in the honors section of Biology 181 at the University of Arizona. Its purpose is to take two scientific papers concerning cell morphology and motility, and to explain them in terms more easily understood by those outside the scientific community.
For guidance on the analysis of the papers Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis and New dimensions in cell migration, we'd like to thank our faculty mentor, Dr. Anne Cress, Professor of Cellular Biology and Anatomy at the University of Arizona. Below you will find two pictures illustrating different types of cell shape, rounded or elongated, as well as some movies that show examples of various cells and their movements. |
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Movie 1. Time-lapse movie of GFP-A375m2 cells moving in 3D Matrigel, the first part of the movie shows a 360 rotation around the cells at a fixed timepoint before animation through the timepoints (timepoints are 450s apart). AVI file (3,632 K) Movie 2. Time-lapse movie of GFP-A375m2 cells moving in 3D Matrigel, the movie shows a single confocal section (timepoints are 30 minutes apart). AVI file (62 K) Movie 3. Time-lapse movie of A375m2 cells on 2D tissue culture plastic in 10%DCS (timepoints are 5 minutes apart). AVI file (3,296 K) Movie 4. Time-lapse movie of A375m2 cells on 2D tissue culture plastic in 10%DCS treated with 10µm Y27632 five hours prior to filming (timepoints are 5 minutes apart). AVI file (3365 K) Download Quicktime or RealPlayer. Movies and pictures courtesy of Nature Cell Biology.
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for Honors Biology 181.