Results --> Metabolism Of Cocaine And Heroin

 

When we ingest cocaine, Molecular man hydrolyzes cocaine into its urinary metabolite

Benzoylecgonine For those of us stupid enough to ingest cocaine and kick back a few

beers, Molecular man will perform a tranesterification with the ethanol of the beer and

the cocaineto make a toxic metabolite, Cocaethlyene. Molecular man derives loads and

loads of pleasure from performing these reactions. Molecular man metabolizes

Heroin into two different steps, because the heroin molecule has two ester groups

(which will give molecular man twice the pleasure) he can hydrolyze one of

the esters and make 6-AcetylMorphine, or he can go for the gold and hydrolyze

6-Acetylmorphine into Morphine. It really depends on whether Molecular man is in the

mood for loving or not. Actually, because Molecular man is a stud, (like Tanner from group

15), he will almost always hydrolyze heroin into Morphine.

 

Courtesy Of" "Structural Basis of Heroin and Cocaine Metabolism by a Promiscuous Human Drug-Processing Enzyme.”

a) shows how HCE1 (molecular man) will hydrolyze cocaine into its urinary metabolite,

or transesterify it into Cocaethylene the presence of booze.

b) shows how HCE1 (molecular man) will hydrolyze Heroin in two steps,

first into -acetylmorphine, and then into Morphine.

 

Please Click On The Links Below To Review The Individual Results

Trimer Hexamer Equilibrium ---- Metabolism Of Cocaine And Heroin