Effects of Catalase Over-expression on Aging mouse





The Debate




     What exactly causes the infirmities of old age?  According to the free-radical theory of aging, oxidative damage caused by ROS (reactive oxygen species) is the main culprit.  This website focuses on a study that partly supports this theory by showing that murine life span can be extended by an overexpression of human catalase in mitochondria.  

     The specific paper that this webpage is based on is Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria by Samuel E. Schriner et al.  Another paper that was used in the construction of this webpage is The Anti-Aging Sweepstakes: Catalase Runs for the ROSes by Richard A. Miller.  These scientific papers are summaries of the experiments carried out by Schriner and his group dealing with the topic of catalase-overexpression and its effect on murine lifespan.  However, it is important to remember that this is a topic still under much debate.  Though these experiments do not provide us with a definat cureall for aging, it is believed by many that the data aquired from them point us to one of the major culprits of aging and age related diseases, ROS's.

     This webpage is a student project created according to the requirements outlined by the Honors Biology 181 Lecture Course at the University of Arizona.  The students who created this project received much appreciated help and advising from Dr. George T. Bowden, a faculty member at the University of Arizona. 

The students involved in this project and their responsibilities are:

  Nina Axan: Aquisition of pictures, Home Page Introduction

  Marcus Dahlstrom: Experiments section

  Kristen Grundy: Introduction section

  Jennifer Kim: Introduction section

  Helen Mashalidis: Experiments section

  Cameron Peek: Introduction section, Text typing and web design

  Brent Riepel: Conclusion section

  Ravi Savajiyani: Web site posting and web desgin

  Andrew Templeton: Experiments section

  Nicole Woodvick: Conclusion section


University of Arizona
Biology 181H 2005 Group 7
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Last Revised: 12/7/05