‘Rejuvenation’ protects neurons in mouse
models of Parkinson’s disease
By Dr. Konrad Zinsmaier
Abstract
Attempts to cure or slow down the progression of Parkinson’s disease have largely failed; researchers in this paper maintain this is obviously a direct result of the lack of insight into the pathogenesis of the disease. Parkinson’s disease is the product of the deaths of a number of dopaminergic (dopamine-secreting) neurons in the substantia nigra pars compacta region (SNc) of the brain. But what causes these deaths? In the paper “‘Rejuvenation’ protects neurons in mouse models of Parkinson’s disease,” Chen and researchers find that older neurons in the SNc are unusually reliant on calcium channels and that after blocking these channels, the cells are “rejuvenated” and begin acting like their juvenile counterparts; as a result, these cells become protected from Parkinson’s disease. Their research, thus, points not only to a possible cause of neuronal death in PD but also to a possible means of curing the disease.