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Dr. Parker B. Antin

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      The differentiated ES cells, as well as the fetal, neonatal, and adult fibroblast cells all regained pluripotency after being treated with the four primary genes expressed in pluripotent ES cells. This characteristic was evaluated by studying morphology, conducting chemical tests, and analyzing whether they formed tumors in immune-deficient mice. However, while somatic cells can apparently be reprogrammed with defined factors, controlling the cells so that they do not develop tumors in humans is the next step. Still, scientists now possess the knowledge and methods necessary for culturing cells that can be used in clinical situations without exploiting ES cells, considered by many to be a serious ethical dilemma.


Group 11

UA Honors Biology 181

November 13, 2008