This site has been dedicated to the further development and understanding of cystic fibrosis, or CF as it is commonly called. To learn more than just the basics of CF, click on one of our informative links.

CF is caused by an inherited recessive genetic defect that is most prevalent in the white population. About 1 in 23 people in the United States carry at least one defective gene, making it the most common genetic defect of its severity. CF patients suffer from chronic lung problems and digestive disorders caused by a cellular defect in the transport of chloride ion. The problem in chloride handling results in loss of chloride in sweat which, in fact, is the basis for the clinical diagnosis of CF. As a consequence of the lesion in chloride transport patients' lungs become covered with sticky mucus which is difficult to remove and can promote infection by bacteria. Many people with CF require frequent hospitalizations and continuous usage of antibiotics, enzyme supplements, and other medications. In the past, the life expectancy of people with CF used to only be 8 years. However, with today's many medical advances, the average life expectancy is just under 30 years and is continuing to increase.

high amounts of salt (sodium and chloride) and potassium in sweat

constant coughing and wheezing

large amounts of mucus in the lungs

recurring pneumonia

failure to gain weight

frequent, greasy, bulky, and strong-smelling bowel movements through the small intestine

enlargement of fingertips and toes due to insufficient amount of oxygen in these areas

Males with CF are sterile, and women who have CF can have problems with their menstrual cycles and becoming pregnant.

CF slows down sexual development but brings no adverse effect upon it.

If you would like more info on CF please visit these other web sites.

This site is associated with the University of Arizona as part of an Honors Biology 181 project. If you have questions or comments, please at rchan@U.Arizona.EDU.